普罗布考对高同型半胱氨酸血症致兔动脉粥样硬化的作用Effects of Probucol on Atherosclerosis in Rabbits Induced by Hyperhomocysteinemia
吴乐,黎红华,武强,王晓昆
摘要(Abstract)：
目的:观察普罗布考对高同型半胱氨酸(Hcy)血症致兔动脉粥样硬化(AS)的作用。方法:将24只大白兔分为对照组、模型组和治疗组各8只,对照组给予基础饲料喂养,模型组和治疗组均在基础饲料中加入1%的蛋氨酸,此外治疗组同时用普罗布考灌胃(1g/d);饮食量200g/d,均喂养20周。分别于第20周末检测血总同型半胱氨酸(tHcy)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。第20周末处死动物,剥离腹主动脉,用Western blot检测血管中核转录因子-κB(NF-κB)蛋白表达,光镜下观察主动脉病理形态学变化。结果:治疗组血中TC、TG、HDL-C和LDL-C水平低于模型组(P<0.05),tHcy水平无统计学差异;治疗组主动脉NF-κB蛋白表达水平明显低于模型组(P<0.05);主动脉病理形态学检查显示治疗组病变轻于模型组。结论:普罗布考能降低血脂,下调NF-κB,减轻内膜增生程度,具有抗AS的作用。
关键词(KeyWords)： 普罗布考;同型半胱氨酸;动脉粥样硬化;核转录因子-κB
基金项目(Foundation):
作者(Author): 吴乐,黎红华,武强,王晓昆
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