唐协林;姚庆宁;夏祥国;黎乾科;刘胜华;肖奎;顾应江;钟俊;赵超;

• 1:三台县人民医院(川北医学院附属三台医院)神经外科
• 2:泸州医学院附属医院神经外科

摘要(Abstract)：

目的:研究家犬脑出血(ICH)模型补体C3、C4与血肿周围脑水肿的关系。方法:30只家犬随机分为正常对照组、影像组和血肿组3组各10只。正常对照组不予任何处理,影像组和血肿组采用立体定向自体血脑内注入法制备ICH模型。正常对照组和影像组分别于术后6 h、24 h、72 h、5 d、7 d检测外周静脉血C3、C4含量,各时间点行头颅CT扫描并计算水肿比值。血肿组分别于术后6 h、24 h、72 h、5 d、7 d检测血肿液C3、C4含量。各时间点采用Purdy PD评分标准评估神经功能缺损。结果:影像组和血肿组外周血、血肿液补体C3、C4含量术后6 h开始升高,72 h达高峰,之后逐渐下降。影像组、血肿组与正常对照组比较,术后6 h外周血C4差异无统计学意义(P>0.05),其余同时间点两两比较差异均有统计学意义(P<0.05)。ICH后Purdy PD评分即有所下降,72 h下降为最低,之后逐渐升高。结论:ICH后补体C3、C4激活可能参与血肿周围脑水肿形成和继发性脑损害的病理过程。

关键词(KeyWords)： 脑出血;免疫组织化学;补体C3;补体C4;脑水肿

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 唐协林;姚庆宁;夏祥国;黎乾科;刘胜华;肖奎;顾应江;钟俊;赵超;

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