李奕欣,周麟,肖玲,王惠玲,王高华

• 1:武汉大学人民医院精神科
• 2:湖北省神经精神病研究所

摘要(Abstract)：

目的：探究孕期运动对青春期雄性后代小鼠焦虑与抑郁样行为影响以及相关机制研究。方法：母鼠怀孕第2天开始受人为控制进行跑轮运动（1 h/d），一直到生产日结束。分娩后每周评估母鼠的母性行为。青春期雄性后代（产后4周）接受为期2周，每天3小时的慢性束缚应激后进行行为学测试，取海马组织检测神经炎症和神经凋亡水平。结果：来自孕期运动增加母鼠母性行为，同时减少青春期后代雄鼠慢性应激后焦虑与抑郁样行为，并抑制海马中的细胞凋亡和NLRP3相关的神经炎症激活。结论：母鼠在怀孕期间进行跑轮运动后，哺乳期间对后代的母性行为增加，减少了青春期雄性后代慢性应激后焦虑和抑郁样行为，其机制可能与抑制了海马神经元凋亡以及NLRP3炎症小体相关的神经炎症激活有关。

关键词(KeyWords)： 孕期运动;怀孕;焦虑;抑郁;NLRP3;细胞凋亡;青春期

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目（NLRP3炎症小体/IL-18/NF-κB神经炎症通路介导抑郁症发生与转归的作用与机制研究，No.81871072）;国家自然科学基金项目（HSP90通过LAMP2A调控伴侣蛋白介导自噬诱导铁死亡在抑郁症发生中的可能机制研究，No.82071523）;; 武汉大学腾飞计划（神经科学疾病与功能协同创新研究，No.TFLC2018001）;; 湖北省重点研发计划（新冠肺炎创伤后应激障碍ptsd发病机制与智能化精准防治，No.2020BCA064)

作者(Author): 李奕欣,周麟,肖玲,王惠玲,王高华

DOI: 10.16780/j.cnki.sjssgncj.20230838

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